Business details
Based on our unique know-how and intellectual property in cell culture, we provide culture medium sales, culture medium development support services and other development support services such as substrate materials, operating methods, and equipment, that provide a bird's-eye view of the entire process.
Culture medium development
Core technology
Protein free technology
One of our achievements is that we succeeded in significantly reducing culture medium costs (approximately 1/100) by replacing all proteins contained in the culture medium with low-molecular compounds in the cardiomyocyte differentiation process from iPS cells. This protein-free technology, which is one of our core technologies, is applicable not only to specific cell types such as iPS cells and cardiomyocytes, but also to the development of other regenerative medicine products.
Culture medium components library
Based on the know-how of culture medium development applying protein-free technology, we have developed culture medium components that allow you to construct the desired culture medium composition by freely combining various basic media and their components, proteins such as cytokines, and culture medium components such as numerous low molecules or lipids. We have maintained the library. We will develop culture medium optimization using this culture medium component library as our core technology.
Culture medium optimization
Utilizing our core technology, we propose solutions to our customers' cell culture issues by optimizing culture medium.
Designing culture media and, Engineering cells.
Many people probably think of the "Engineering cells" method as modification through genome editing. We have developed a method to modify cell phenotype using culture media. For example, by controlling metabolism and cell fate, it is possible to increase the drug responsiveness of iPS cell-derived cardiomyocytes, or while maintaining the undifferentiated T cells and promoting their proliferation, the difference in culture medium composition makes ratio of killer T cells to helper T cells to change.
In regenerative medicine, properties such as quality and proliferation vary greatly depending on the culture medium components and concentrations added at specific timings during the cell processing process. By optimizing the culture medium, we will design cells and contribute to the realization of a world where cell products that can treat various diseases are created one after another.
Product sales
iPS cell-derived cardiomyocytes developed using our core technology, the protein-free method, have a repertoire of human and monkey cells.
In addition, we are developing various culture medium products based on our media component library, including serum-free growth media adapted to various cells and serum-free culture medium specialized for mesenchymal stem cells. Based on these medium, we also propose culture medium optimization.
Drug discovery supports・Development of cell culture technology
Drug discovery supports
We have started supporting drug discovery research centered on the technology for inducing differentiation of iPS cells into cardiomyocytes (complete protein-free differentiation induction method), which was the core technology at the time of Myoridge's establishment. While utilizing our experience in developing evaluation models using iPS cell-derived cardiomyocytes, we are expanding our contract items, including the production of cells introduced with various sensor proteins and the development of heart disease models using genome editing technology. We also support in vitro model development through culture medium optimization using our unique medium component library.
Development of cell culture technology
In developing culture medium for regenerative medicine, it is necessary to develop media using raw materials that can handle living primordium, or to be animal-free or xeno-free. In addition, the development of culture devices is actively being carried out around the world, and we aim to build new culture technologies by outsourcing and conducting joint research with manufacturers that develop new materials. We would like to help you.
